1. Bouchard-Cannon P, Lowden C, Trinh D, Cheng HM. Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche. Sci Rep. 2018;8:5294.
  2. Mendoza-Viveros L, Obrietan K, Cheng HM. Commentary: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock. J Neurol Neuromedicine. 2018;3(1):21-25.
  3. Stefanelli G*, Azam AB*, Walters BJ, Brimble MA, Gettens CP, Bouchard-Cannon P, Cheng HM, Davidoff AM, Narkaj K, Day JJ, Kennedy AJ, Zovkic IB. Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus. Cell Rep. 2018 Jan 30;22(5):1124-1131. doi: 10.1016/j.celrep.2018.01.020. (*equal contribution)
  4. Zhang P, Li G, Li H, Tan XQ, Cheng HM. Environmental perturbation of the circadian clock during pregnancy leads to transgenerational mood disorder-like behaviors in mice. Sci Rep. 2017 Oct 3;7(1):12641. doi: 10.1038/s41598-017-13067-y.
  5. Mendoza-Viveros L, Chiang CK, Ong JLK, Hegazi S, Cheng AH, Bouchard-Cannon P, Fana M, Lowden C, Zhang P, Bothorel B, Michniewicz MG, Magill ST, Holmes MM, Goodman RH, Simonneaux V, Figeys D, Cheng HM. miR-132/212 modulates seasonal adaptation and dendritic morphology of the central circadian clock. Cell Rep. 2017 Apr 18;19(3):505-520. doi: 10.1016/j.celrep.2017.03.057
  6. Chiang CK, Xu B, Mehta N, Mayne J, Sun WY, Cheng K, Ning Z, Dong J, Zou H, Cheng HM, Figeys D. Phosphoproteome Profiling Reveals Circadian Clock Regulation of Posttranslational Modifications in the Murine Hippocampus. Front Neurol. 2017 Mar 22;8:110. doi: 10.3389/fneur.2017.00110. eCollection 2017.
  7. Peragine DE, Pokarowski M, Mendoza-Viveros L, Swift-Gallant A, Cheng HM, Bentley GE, Holmes MM. RFamide-related peptide-3 (RFRP-3) suppresses sexual maturation in a eusocial mammal. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1207-1212. doi: 10.1073/pnas.1616913114.
  8. Mendoza-Viveros L*, Bouchard-Cannon P*, Hegazi S*, Cheng AH, Pastore S, Cheng HM. Molecular modulators of the circadian clock: lessons from flies and mice. Cell Mol Life Sci. 2017 Mar;74(6):1035-1059. doi: 10.1007/s00018-016-2378-8. Review. (*equal contribution)
  9. Mendoza-Viveros L*, Cheng AH*, Cheng HM. GRK2: putting the brakes on the circadian clock. Receptors Clin Investig. 2016 Feb 1;3(1). doi: 10.14800/rci.1175. (*equal contribution)
  10. Mehta N*, Cheng AH*, Chiang CK*, Mendoza-Viveros L*, Ling HH, Patel A, Xu B, Figeys D, Cheng HY. GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins. Cell Rep. 2015 Aug 25;12(8):1272-88. doi: 10.1016/j.celrep.2015.07.037. (*equal contribution)
  11. Ramzan F, McPhail M, Rao P, Mo K, Halievski K, Swift-Gallant A, Mendoza-Viveros L, Cheng HY, Monks DA. Distinct Etiological Roles for Myocytes and Motor Neurons in a Mouse Model of Kennedy’s Disease/Spinobulbar Muscular Atrophy. J Neurosci. 2015 Apr 22;35(16):6444-51. doi: 10.1523/JNEUROSCI.3599-14.2015.
  12. Chiang CK, Mehta N, Patel A, Zhang P, Ning Z, Mayne J, Sun WY, Cheng HY, Figeys D. The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes. PLoS Genet. 2014 Oct 16;10(10):e1004695. doi: 10.1371/journal.pgen.1004695.
  13. Ling HH, Beaulé C, Chiang CK, Tian R, Figeys D, Cheng HY. Time-of-day- and light-dependent expression of ubiquitin protein ligase E3 component N-recognin 4 (UBR4) in the suprachiasmatic nucleus circadian clock. PLoS One. 2014 Aug 1;9(8):e103103. doi: 10.1371/journal.pone.0103103.
  14. Ling HH, Mendoza-Viveros L, Mehta N, Cheng HY. Raf kinase inhibitory protein (RKIP): functional pleiotropy in the mammalian brain. Crit Rev Oncog. 2014;19(6):505-16. Review.
  15. Bouchard-Cannon P, Mendoza-Viveros L, Yuen A, Kærn M, Cheng HY. The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep. 2013 Nov 27;5(4):961-73. doi: 10.1016/j.celrep.2013.10.037.
  16. Bouchard-Cannon P, Cheng HY. Scheduled feeding alters the timing of the suprachiasmatic nucleus circadian clock in dexras1-deficient mice. Chronobiol Int. 2012 Oct;29(8):965-81. doi: 10.3109/07420528.2012.707264.
  17. Mehta N, Cheng HY. Micro-managing the circadian clock: The role of microRNAs in biological timekeeping. J Mol Biol. 2013 Oct 9;425(19):3609-24. doi: 10.1016/j.jmb.2012.10.022. Review.
  18. Antoun G, Bouchard-Cannon P, Cheng HY. Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by Raf kinase inhibitor protein. J Neurosci. 2012 Apr 4;32(14):4867-77. doi: 10.1523/JNEUROSCI.5650-11.2012.
  19. Beaulé C, Cheng HY. The acetyltransferase Clock is dispensable for circadian aftereffects in mice. J Biol Rhythms. 2011 Dec;26(6):561-4. doi: 10.1177/0748730411416329.
  20. Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature. 2011 Nov 9;480(7376):209-14. doi: 10.1038/nature10649.
  21. Tian R, Alvarez-Saavedra M, Cheng HY, Figeys D. Uncovering the proteome response of the master circadian clock to light using an AutoProteome system. Mol Cell Proteomics. 2011 Nov;10(11):M110.007252. doi: 10.1074/mcp.M110.007252.
  22. Koletar MM, Cheng HY, Penninger JM, Ralph MR. Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 2011 Aug;28(7):553-62. doi: 10.3109/07420528.2011.592235.
  23. Alvarez-Saavedra M, Antoun G, Yanagiya A, Oliva-Hernandez R, Cornejo-Palma D, Perez-Iratxeta C, Sonenberg N, Cheng HY. miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Hum Mol Genet. 2011 Feb 15;20(4):731-51. doi: 10.1093/hmg/ddq519.
  24. Cheng HY, Alvarez-Saavedra M, Dziema H, Choi YS, Li A, Obrietan K. Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain. Hum Mol Genet. 2009 Aug 15;18(16):3110-24. doi: 10.1093/hmg/ddp252.
  25. Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY, Marks D, Obrietan K, Soderling TR, Goodman RH, Impey S. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9093-8. doi: 10.1073/pnas.0803072105.
  26. Cheng HY, Obrietan K. Revealing a role of microRNAs in the regulation of the biological clock. Cell Cycle. 2007 Dec 15;6(24):3034-5. Review.
  27. Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K. microRNA modulation of circadian-clock period and entrainment. Neuron. 2007 Jun 7;54(5):813-29.
  28. Huang H, Acuna-Goycolea C, Li Y, Cheng HM, Obrietan K, van den Pol AN. Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal. J Neurosci. 2007 May 2;27(18):4870-81.
  29. Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 2006 Dec 13;26(50):12984-95.
  30. Cheng HY, Obrietan K. Dexras1: shaping the responsiveness of the circadian clock. Semin Cell Dev Biol. 2006 Jun;17(3):345-51. Review.
  31. Butcher GQ, Lee B, Cheng HY, Obrietan K. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. J Neurosci. 2005 Jun 1;25(22):5305-13.
  32. Cheng HY, Penninger JM. DREAMing about arthritic pain. Ann Rheum Dis. 2004 Nov;63 Suppl 2:ii72-ii75. Review.
  33. Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 2004 Sep 2;43(5):715-28.
  34. Cheng HY, Laviolette SR, van der Kooy D, Penninger JM. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci. 2004 Jun;19(11):3033-41.
  35. Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 2004 Mar;6(3):215-26.
  36. Cheng HY, Penninger JM. When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opin Ther Targets. 2003 Apr;7(2):249-63. Review.
  37. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002 Sep 20;110(6):737-49.
  38. Cheng HY, Penninger JM. Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Expert Rev Neurother. 2002 Sep;2(5):677-89. doi: 10.1586/14737175.2.5.677.
  39. Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM. DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002 Jan 11;108(1):31-43.
  40. Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB. Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 2001 Nov 2;276(44):41005-13.
  41. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zúñiga-Pflücker JC, Kroemer G, Penninger JM. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001 Mar 29;410(6828):549-54.
  42. Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001 Jan 18;409(6818):349-54.
  43. Liu SL, Hessel A, Cheng HY, Sanderson KE. The XbaI-BlnI-CeuI genomic cleavage map of Salmonella paratyphi B. J Bacteriol. 1994 Feb;176(4):1014-24.


  1. Cheng HYM, Obrietan K. Transcriptional Mechanisms Underlying the Mammalian Circadian Clock. In Transcriptional Regulation by Neuronal Activity (Dudek SM, Ed.), pp.313-336. Springer US.
  2. Cheng HYM, Penninger JM. DREAM/KChIP3/Calsenilin: a Multifunctional Player in Health and Disease. In Neuronal Calcium Sensor Proteins (Philippov PP and Koch KW, Eds.), pp.245-270. Nova Science Publishers Inc.


  1. Pastore S, Cheng HYM. DREAM (Downstream Regulatory Element Antagonist Modulator). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).
  2. Cheng AH, Cheng HYM. GRK2 (G Protein-Coupled Receptor Kinase 2). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).
  3. Lowden C, Cheng HYM. GRK5 (G Protein-Coupled Receptor Kinase 5). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).
  4. Mendoza-Viveros L, Cheng HYM. PEBP-1 (Phosphatidylethanolamine Binding Protein 1). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).
  5. Bouchard-Cannon P, Cheng HYM. RASD1 (Ras Related Dexamethasone Induced 1). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).
  6. Hegazi S, Levine JD, Cheng HYM. UBR4 (Ubiquitin Ligase E3 Component N-Recognin 4). In Encyclopedia of Signaling Molecules, 2nd Edition (Choi S, Ed.), Springer Meteor (in press).